Dyston | Iranian Botulinum Toxin
Dyston is a pharmaceutical formulation of botulinum toxin type A that has been available in the Iranian market since 2019 as an Iranian botulinum toxin product. Developed as a biosimilar to the international product Dysport, Dyston is backed by local biotechnology expertise and has quickly earned a strong position in the domestic market thanks to its high quality and reliable clinical performance. With a favorable onset of action, stable therapeutic results, and strict manufacturing standards, Dyston is a trusted option for both aesthetic and therapeutic use.
Developed using indigenous biotechnology
Cost-effective and reliable for physicians
Quality competitive with international alternatives
Suitable for both domestic and export markets
Dyston Applications
Aesthetic Applications
Glabellar lines
Reduces vertical frown lines between the eyebrows
Crow’s feet
Softens fine lines around the eyes
Gummy smile correction
Creates a more balanced smile by controlling excessive upper-lip elevation
Brow lift
Provides a fresher, more lifted appearance with subtle brow elevation
Masseter reduction and jawline contouring
Reduces jaw muscle bulk and may help improve teeth grinding
Improvement of chin and neck lines
Helps soften chin dimpling and vertical bands in the neck
Forehead lines
Smooths horizontal forehead wrinkles
Therapeutic Applications
Chronic migraine
Helps reduce the frequency and intensity of attacks
Excessive sweating (hyperhidrosis)
Helps reduce sweat gland activity
Muscle spasm
Helps relieve involuntary contractions
Cervical dystonia
Helps control abnormal neck movements
Blepharospasm
Helps control involuntary eyelid contractions
Speech-related disorders
May help improve laryngeal spasm, speech, and swallowing difficulties
Emerging Research Applications
Including areas such as gastroparesis, appetite control, and depression
Aesthetic Applications
Glabellar lines
Reduces vertical frown lines between the eyebrows
Forehead lines
Smooths horizontal forehead wrinkles
Crow’s feet
Softens fine lines around the eyes
Gummy smile correction
Creates a more balanced smile by controlling excessive upper-lip elevation
Brow lift
Provides a fresher, more lifted appearance with subtle brow elevation
Masseter reduction and jawline contouring
Reduces jaw muscle bulk and may help improve teeth grinding
Improvement of chin and neck lines
Helps soften chin dimpling and vertical platysmal bands in the neck
Therapeutic Applications
Chronic migraine
Helps reduce the frequency and intensity of attacks
Excessive sweating (hyperhidrosis)
Helps reduce sweat gland activity
Muscle spasm
Helps relieve involuntary contractions
Cervical dystonia
Helps control abnormal neck movements
Blepharospasm
Helps control involuntary eyelid contractions
Speech-related disorders
May help improve laryngeal spasm, speech, and swallowing difficulties
Emerging Research Applications
Including areas such as gastroparesis, appetite control, and depression
خط اخم
کاهش خطوط عمودی بین دو ابرو
خطوط پیشانی
صاف شدن چینهای افقی پیشانی
چینهای پنجهکلاغی دور چشم
کاهش خطوط ظریف اطراف چشم
اصلاح لبخند لثهای
لبخند متعادل با کنترل بالا رفتن لب بالا
لیفت ابرو
شادابتر شدن نگاه با بالا بردن ملایم ابروها
کوچکسازی ماسیتر و فرمدهی فک
کاهش حجم عضله فک و بهبود دندانقروچه
What Is Dyston and How Does It Work?
Botulinum toxin (BoNT) is a highly potent neurotoxin produced by the anaerobic bacterium Clostridium botulinum. This toxin family includes seven distinct subtypes, of which type A is the most potent and the most widely used in medicine. To date, more than 20 clinical and therapeutic applications have been identified for botulinum toxin type A across aesthetics, neurology, and broader medical practice.
Mechanistically, botulinum toxin acts at the neuromuscular junction, where it inhibits the release of the neurotransmitter acetylcholine. This prevents muscle contraction and leads to a controlled, temporary muscle relaxation. This mechanism is central to reducing wrinkles, dynamic facial lines, and a range of therapeutic conditions.
Dyston is available in two dosage strengths:
- Dyston 500 Units – green packaging
- Dyston 300 Units – blue packaging
Clinical Efficacy Comparison: Dysport vs. Dyston
Dysport®
Clinical response to Dysport shows a gradual but sustained decline over time after injection. The highest response is typically observed on Day 14, with progressive reduction through Day 120, reflecting the classic duration pattern of botulinum toxin type A.
Dyston®
In this clinical study, Dyston demonstrated an efficacy profile very close to Dysport. The findings confirmed that, in the per-protocol population, Dyston was non-inferior to Dysport in terms of clinical efficacy and provided a comparable therapeutic response.
Important Safety and Care Instructions
- Discontinue medications such as aspirin, ibuprofen, and blood-thinning supplements at least 10 days before injection
- The injection site should be cleansed with standard disinfectants
- If you have a history of allergy to human albumin or milk proteins, inform your physician
- Avoid washing the face for 4–6 hours
- Avoid using makeup for 12 hours
- Do not massage the treated area for 24 hours
- Avoid direct sun exposure and use sunscreen
- In case of mild swelling or bruising, a cold compress may be used
Why Dyston?
Long-lasting and Stable Performance
Dyston typically begins to take effect within 3 to 10 days after injection and, depending on the treatment area and patient characteristics, may last 2 to 6 months. In some specific production batches, durability of up to 5 months has also been reported.
Easy Injection with Minimal Discomfort
Its lyophilized formulation with a clear diluent allows for quick preparation and precise injection. The injection process is standardized and is generally painless or associated with minimal discomfort.
Consistent Quality Across Production Batches
Manufactured under GMP conditions, using standard stabilizing agents such as human albumin and lactose, and supported by multi-stage quality control, Dyston offers consistent performance across different batches.
Confirmed Safety and Efficacy
Official studies and clinical data approved by the Iranian Ministry of Health indicate that Dyston has a high safety profile and efficacy comparable to reputable international brands.
Cost-Effective Pricing
Compared with imported alternatives, the price per unit of Dyston is up to 30% lower. Pharmacoeconomic analyses also suggest a more favorable cost-to-QALY ratio.
Why Dyston?
Long-lasting and Stable Performance
Dyston typically begins to take effect within 3 to 10 days after injection and, depending on the treatment area and patient characteristics, may last 2 to 6 months. In some specific production batches, durability of up to 5 months has also been reported.
Consistent Quality Across Production Batches
Manufactured under GMP conditions, using standard stabilizing agents such as human albumin and lactose, and supported by multi-stage quality control, Dyston offers consistent performance across different batches.
Easy Injection with Minimal Discomfort
Its lyophilized formulation with a clear diluent allows for quick preparation and precise injection. The injection process is standardized and is generally painless or associated with minimal discomfort.
Confirmed Safety and Efficacy
Official studies and clinical data approved by the Iranian Ministry of Health indicate that Dyston has a high safety profile and efficacy comparable to reputable international brands.
Cost-Effective Pricing
Compared with imported alternatives, the price per unit of Dyston is up to 30% lower. Pharmacoeconomic analyses also suggest a more favorable cost-to-QALY ratio.
FAQ
Dyston is an Iranian botulinum toxin product manufactured by Atra Zist Aray (Imen Vaksan Alborz). It contains botulinum toxin type A and is supplied in 300-unit and 500-unit vials with approval from the Iranian Ministry of Health.
Dyston has shown clinical efficacy comparable to Dysport. Compared with Masport, the more consistent batch-to-batch quality of Dyston may offer better predictability in injection outcomes and a lower risk of unwanted variability.
The effect typically begins within 3 to 10 days, and peak clinical benefit may last for up to 6 months, depending on the indication and patient factors.
Side effects are usually mild and temporary, such as redness, bruising, swelling, or headache. Serious side effects are very rare and are most often associated with improper injection technique.
Dyston is used in aesthetic treatments, chronic migraine, muscle spasms, excessive sweating, and a range of other therapeutic and emerging investigational applications.
بوتولینوم توکسین نوع آ
دیستون فرم دارویی بوتولینوم توکسین نوع” آ” می باشد که از سال 1398 بعنوان بوتاکس ایرانی به بازار کشور عرضه شده است. دانش فنی این محصول به همت پژوهشگران ایرانی بصورت بایوسیمیلار از نمونه خارجی دیسپورت توسعه یافته است. دیستون به علت کیفیت بالا و اثرگذاری مناسب در بازه زمانی کوتاه سهم قابل توجهی از بازار داخلی را به خود اختصاص داده و از طرفی دیگر، بعنوان یک محصول رقابتی و صادراتی بسیار مورد توجه کشورهای دیگر خصوصا کشورهای همسایه قرار گرفته است.
بوتولینوم توکسین (BoNT)، یک نوروتوکسین بسیار قوی است که توسط باکتری بی هوازی کلاستریدیوم بوتولینوم Clostridium botulinum تولید می شود. از هفت زیرخانواده متعلق به این خانواده، نوروتوکسین نوع “آ” (A) قوی ترین و موثرترین نوع بوده که در صنعت درمان بیش از 20 نقش بالینی برای آن معرفی شده است.
از نظر ساختاری این توکسین، پروتیئنی با وزن مولکولی 150 کیلودالتون است که از یک زنجیره ی سنگین به وزن 100 کیلو دالتون و یک زنجیره ی سبک به وزن 50 کیلو دالتون تشکیل شده است و توسط یک باند دی-سولفیدی بهم متصل شده اند. از نظر عملکرد این سم قادر است در محل ارتباط عصب-عضله، با مهار پیامرسان عصبی استیل کولین، انقباض عضلانی را کنترل و مهار کند و از این طریق موجب رفع چین و چروک و خطوط صورت می گردد. محصول دیستــون در دو فرم دارویـی 500 Unit (بسته بندی سبز رنگ) و 300 Unit (بسته بندی آبی رنگ) ارائه می گردد.
بسته بندی دیستون اختصاصی بوده و شامـل موارد زیر مـی باشد:
- یک عــدد ویال دارویــی 2R حاوی مـاده دارویــی لیوفیلیـــزه شده
- یک عدد سرم فیزیولوژی (سدیم کلراید %9/0 تزریقی) – 5 میلی لیتر
- برگه راهنما فارسی-انگلیسی محصول
بوتولینوم توکسین نوع آ
دیستون فرم دارویی بوتولینوم توکسین نوع” آ” می باشد که از سال 1398 بعنوان بوتاکس ایرانی به بازار کشور عرضه شده است. دانش فنی این محصول به همت پژوهشگران ایرانی بصورت بایوسیمیلار از نمونه خارجی دیسپورت توسعه یافته است. دیستون به علت کیفیت بالا و اثرگذاری مناسب در بازه زمانی کوتاه سهم قابل توجهی از بازار داخلی را به خود اختصاص داده و از طرفی دیگر، بعنوان یک محصول رقابتی و صادراتی بسیار مورد توجه کشورهای دیگر خصوصا کشورهای همسایه قرار گرفته است. بوتولینوم توکسین (BoNT)، یک نوروتوکسین بسیار قوی است که توسط باکتری بی هوازی کلاستریدیوم بوتولینوم Clostridium botulinum تولید می شود. از هفت زیرخانواده متعلق به این خانواده، نوروتوکسین نوع “آ” (A) قوی ترین و موثرترین نوع بوده که در صنعت درمان بیش از 20 نقش بالینی برای آن معرفی شده است.
از نظر ساختاری این توکسین، پروتیئنی با وزن مولکــولی 150 کیــلودالتون اســت که از یـک زنجیره ی سنگین به وزن 100 کیلو دالتون و یک زنجیره ی سبک به وزن 50 کیلو دالتون تشکیل شده است و توسط یک باند دی-سولفیدی بهم متصل شده اند. از نظر عملکرد این سم قادر است در محل ارتباط عصب-عضله، با مهار پیامرسان عصبی استیل کولین، انقباض عضلانی را کنترل و مهار کند و از این طریق موجب رفع چین و چروک و خطوط صورت می گردد. محصول دیستــون در دو فرم دارویـی 500 Unit (بسته بندی سبز رنگ) و 300 Unit (بسته بندی آبی رنگ) ارائه می گردد. بسـته بندی دیستــون اختصـاصی بوده و شامل موارد زیر می باشد:
- یک عدد ویال دارویی 2R حاوی مـاده دارویی لیوفیلیزه شده
- یک عدد سرم فیزیولوژی (سدیم کلراید %9/0 تزریقی) – 5 میلی لیتر
- برگه راهنما فارسی-انگلیسی محصول
Buy orginal Dyston
To ensure authenticity and efficacy, purchase only from authorized providers. For administration by a qualified physician only.